Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction
Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J
Published in Journal of Applied Physiology
Methodology
Randomized, double-blind crossover trial of nitrate-rich beetroot juice (16 mmol nitrate/day) versus nitrate-depleted placebo for 5 days with 2-week washout in patients with HFrEF
Key Findings
Plasma nitrate rose 933% and nitrite 94% after supplementation, but improvements in exercise capacity, endothelial function and mitochondrial respiration were limited.
Conclusions
Short-term inorganic nitrate markedly raises NO precursors but yields limited functional gains in HFrEF.
Limitations
Small sample (16, predominantly men), 5-day supplementation only.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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