rct
    2019
    High Quality

    The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: a randomized placebo-controlled study

    Ellegaard PK, Licht RW, Nielsen RE

    Published in Journal of Affective Disorders

    Methodology

    20-week randomised placebo-controlled trial of adjunctive NAC 2 g/day in acute bipolar depression.

    Key Findings

    No difference between NAC and placebo on MADRS depression scores or response rates.

    Conclusions

    Adjunctive NAC did not improve acute bipolar depression.

    Limitations

    Modest sample size; acute-phase population differs from maintenance trials.

    Supplements Studied

    No difference between NAC and placebo in acute bipolar depression.

    Outcomes Measured

    Depression Symptom Reduction

    NAC did not improve MADRS scores in acute bipolar depression.

    Related Health Concerns

    Bipolar Disorder
    Depression

    Study Details

    Year:2019
    Sample Size:80
    Quality Score:8/10

    Access Study

    View on DOIView on PubMedOriginal Source

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