L-arginine supplementation fails to improve outcomes after acute myocardial infarction: the VINTAGE MI randomized trial
Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S
Published in JAMA
Methodology
Randomized double-blind placebo-controlled trial of L-arginine added to standard therapy after myocardial infarction.
Key Findings
L-arginine did not improve vascular stiffness or ejection fraction and was associated with more deaths, prompting early termination.
Conclusions
Boosting nitric oxide precursors is not beneficial and may be harmful in older post-infarction patients.
Limitations
Older post-infarction population; trial stopped early.
Supplements Studied
L-arginine did not improve vascular stiffness and was associated with more deaths
Outcomes Measured
L-arginine did not improve vascular stiffness or ejection fraction and was associated with more deaths
Study Details
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