Glutamine supplementation in critically ill and surgical patients: an updated meta-analysis of randomised trials
Tao KM, Li XQ, Yang LQ, Yu WF, Lu ZJ, Sun YM
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane review and meta-analysis of 53 randomised trials of glutamine supplementation in critically ill and surgical adults
Key Findings
Glutamine had no effect on mortality but was associated with a moderate reduction in infectious complications and shorter hospital stay; effects diminished in low-risk-of-bias trials.
Conclusions
Any benefit of clinical glutamine is limited to infection and length of stay, with no survival advantage.
Limitations
Heterogeneous routes and doses; several trials at high risk of bias.
Supplements Studied
Glutamine supplementation showed no effect on mortality but was associated with a reduction in infectious complications and length of hospital stay.
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.