Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review of randomised controlled trials comparing high-dose oral (1000-2000 mcg/day) with intramuscular vitamin B12 in adults with B12 deficiency.
Key Findings
High-dose oral vitamin B12 produced serum B12 levels comparable to or higher than intramuscular administration at 3 months, with similar effects on haematological and neurological outcomes.
Conclusions
Oral high-dose B12 may be as effective as intramuscular administration for correcting deficiency, offering a less invasive and cheaper route.
Limitations
Only three small trials met inclusion criteria; evidence graded low quality; short follow-up.
Supplements Studied
High oral doses of vitamin B12 (1000 mcg and 2000 mcg) were as effective as intramuscular administration in obtaining short term haematological and neurological responses in vitamin B12 deficient patients.
Outcomes Measured
High oral doses of vitamin B12 were as effective as intramuscular administration in obtaining short term haematological and neurological responses in vitamin B12 deficient patients.
Related Health Concerns
Study Details
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Disclosures
Funding
No external commercial funding reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.