rct
    2010
    High Quality

    S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial

    Papakostas GI, Mischoulon D, Shyu I, Alpert JE, Fava M

    Published in American Journal of Psychiatry

    Key Findings

    SAMe 800 mg twice daily added to SSRIs raised response rates to 36 percent versus 18 percent with placebo augmentation.

    Conclusions

    SAMe may help SSRI non-responders as an adjunct.

    Limitations

    Six week trial; modest sample; single centre.

    Supplements Studied

    SAM-e
    Compound

    SAMe 800 mg twice daily added to SSRIs raised response rates to 36 percent versus 18 percent with placebo augmentation.

    L-Methionine
    Amino Acid

    SAMe 800 mg twice daily added to SSRIs raised response rates to 36 percent versus 18 percent with placebo augmentation.

    Related Health Concerns

    Depression

    Study Details

    Year:2010
    Sample Size:73
    Duration:6 weeks
    Quality Score:7/10

    Access Study

    View on DOIOriginal Source

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.