Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis
Wu R
Published in Journal of Cosmetic Dermatology
Methodology
Systematic review and meta-analysis of observational studies comparing serum trace element and vitamin concentrations between alopecia areata patients and healthy controls, pooling standardized mean differences.
Key Findings
Pooled case-control data showed patients with alopecia areata had significantly lower serum vitamin D and zinc concentrations than controls, while other trace elements showed no consistent association.
Conclusions
Our research provided evidence that the levels of serum VD and zinc were associated with the risk of AA. Supplementation with VD and zinc may become a potential treatment for AA.
Limitations
Built on cross-sectional and case-control studies, so causal direction is unknown and low levels may follow rather than cause disease; heterogeneous assays and populations; no supplementation trial evidence.
Supplements Studied
The levels of serum VD and zinc were associated with the risk of AA. Supplementation with VD and zinc may become a potential treatment for AA.
Pooled case-control data showed patients with alopecia areata had significantly lower serum vitamin D and zinc concentrations than controls, while other trace elements showed no consistent association.
Outcomes Measured
The results of meta-analysis demonstrated patients with AA had a lower serum level of vitamin D (SMD = -0.93 ng/mL) and serum zinc (SMD = -0.69 microg/dL) than the healthy controls
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.