Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society clinical practice guideline
Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ
Published in Journal of Clinical Endocrinology & Metabolism
Methodology
Evidence-based clinical practice guideline developed with systematic reviews and GRADE methodology for primary adrenal insufficiency.
Key Findings
Glucocorticoid and mineralocorticoid replacement remain the standard of care; patients require stress dosing and emergency hydrocortisone, and routine DHEA is not recommended.
Conclusions
Addison's disease requires lifelong prescription hormone replacement; supplements cannot substitute for glucocorticoid therapy.
Limitations
Guideline synthesis rather than primary trial data; limited randomised evidence for several recommendations.
Related Health Concerns
Study Details
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