Effect of Omega-3 Polyunsaturated Fatty Acid Supplements on Cognitive Performance in Patients with Mild Cognitive Impairment or Alzheimer's Disease: A Systematic Review and Meta-Analysis
Khatun M, et al.
Published in Nutrition Reviews
Methodology
Systematic review and meta-analysis of randomized controlled trials of omega-3 PUFA supplementation in patients with mild cognitive impairment or Alzheimer's disease, pooling domain-specific cognitive outcomes.
Key Findings
Omega-3 PUFA supplementation improved Full-Scale IQ, information-processing speed and working memory/attention in mild cognitive impairment or Alzheimer's disease, while effects on global cognition and other domains were inconsistent.
Conclusions
Omega-3 PUFA treatment improved Full-Scale IQ, information processing, and working memory/attention domains, with inconsistency across other outcomes.
Limitations
Heterogeneous EPA/DHA doses and trial durations, varied cognitive instruments, small individual trials, and likely greater benefit in earlier-stage disease than established dementia.
Supplements Studied
Our findings have provided evidence of the effectiveness of an n-3 PUFA treatment in improving Full-Scale IQ (FSIQ)... information processing... and digit span/working memory/attention aspects of cognitive functioning.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.