Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study
Haubenberger D
Published in Neurology
Methodology
Randomized, double-blind, placebo-controlled crossover study of a single oral dose of octanoic acid in patients with alcohol-responsive essential tremor, using accelerometric tremor amplitude and clinical tremor rating scales.
Key Findings
Single-dose octanoic acid did not significantly reduce tremor amplitude at the primary timepoint, but accelerometry showed greater tremor reduction than placebo at later timepoints, with good tolerability.
Conclusions
Although the effects of OA and placebo at the primary outcome were not different, secondary outcome measures suggest superiority of OA in reducing tremor at later time points, warranting further trials at higher dose levels.
Limitations
Very small sample (n=19), single low dose, acute single-session design with no data on sustained use, and negative primary endpoint.
Related Health Concerns
Study Details
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Disclosures
Funding
Intramural Research Program of the National Institute of Neurological Disorders and Stroke, NIH.
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