300,000 IU or 600,000 IU of oral vitamin D3 for treatment of nutritional rickets: a randomized controlled trial
Mittal H, Rai S, Shah D, Madhu SV, Mehrotra G, Malhotra RK, et al.
Published in Indian Pediatr, Vol. 51 (4), pp. 265-72
Methodology
Open-label randomised non-inferiority trial in 76 children (median age 12 months) with radiologically confirmed rickets, given 300,000 IU or 600,000 IU of oral vitamin D3 as a single-day dose.
Key Findings
Radiological healing occurred in all children by 12 weeks and serum 25-hydroxyvitamin D rose in both groups. Hypercalcaemia was documented in 2 children at 4 weeks and 3 at 12 weeks. 63% still had 25-hydroxyvitamin D below 20 ng/mL at 12 weeks.
Conclusions
300,000 IU was comparable to 600,000 IU, although the authors judged the risk of hypercalcaemia unacceptably high in both groups and neither regimen normalised vitamin D status in most children.
Limitations
Open-label, single centre, no daily-dose comparator; 16 of 76 children lacked a 12-week vitamin D result.
Supplements Studied
Radiological healing occurred in all children by 12 weeks
Related Health Concerns
Study Details
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