N-acetylcysteine and glutathione precursor supply in glutathione deficiency: mechanisms and clinical implications
Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F
Published in American Journal of Clinical Nutrition
Methodology
Randomised trial of cysteine and glycine precursor supplementation for 14 days in older adults with low glutathione, with stable-isotope measurement of glutathione synthesis
Key Findings
Precursor supplementation restored erythrocyte glutathione synthesis and concentrations to youthful levels and lowered oxidative stress markers.
Conclusions
Supplying glycine and cysteine precursors is an effective route to raising glutathione, an alternative to direct glutathione dosing.
Limitations
Small sample; short intervention; surrogate endpoints only.
Supplements Studied
Supplementing elderly subjects with the glutathione precursors cysteine and glycine fully restored glutathione synthesis and concentrations and lowered oxidative stress.
Study Details
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