Vitamin D for the management of multiple sclerosis
Jagannath VA, et al
Published in Cochrane Database of Systematic Reviews
Methodology
Cochrane systematic review and meta-analysis of randomized controlled trials of vitamin D in people with multiple sclerosis, with relapse, disability progression, MRI outcomes and adverse events assessed using GRADE.
Key Findings
Across included trials, vitamin D supplementation did not reduce relapse rate, disability progression or MRI lesion activity in multiple sclerosis, though it was well tolerated; evidence certainty was very low.
Conclusions
To date, very low-quality evidence suggests no benefit of vitamin D for patient-important outcomes among people with MS.
Limitations
Small heterogeneous trials with varied doses and formulations, short follow-up relative to MS progression, and high risk of bias in several studies.
Supplements Studied
To date, very low-quality evidence suggests no benefit of vitamin D for patient-important outcomes among people with MS.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.