Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials
Rounagh M, Musazadeh V, Hosseininejad-Mohebati A, Falahatzadeh M, Kavyani Z
Published in Clinical Nutrition ESPEN
Methodology
Systematic review and meta-analysis of 34 RCTs using random-effects models and standardized mean differences.
Key Findings
Significant reductions in total cholesterol (SMD -1.78), triglycerides (SMD -1.27) and LDL-C (SMD -2.45), with a significant increase in HDL-C (SMD 0.79).
Conclusions
Nigella sativa may be useful as an adjuvant anti-hyperlipidemic agent.
Limitations
Very large effect sizes with substantial heterogeneity, mostly small trials, publication bias plausible.
Supplements Studied
N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: -1.78; 95% CI: -2.20, -1.37, p < 0.001), triglycerides (TG) (SMD: -1.2725) and low-density lipoprotein cholesterol (LDL-C) (SMD: -2.45)
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.