Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial
Nowak A, Boesch L, Andres E
Published in Medicine
Methodology
Double-blind randomized placebo-controlled trial of a single oral bolus of vitamin D3 in vitamin D-deficient but otherwise healthy adults reporting fatigue, using a validated fatigue assessment scale over 4 weeks.
Key Findings
A single high dose of vitamin D3 significantly reduced self-perceived fatigue scores at four weeks compared with placebo in otherwise healthy adults with vitamin D deficiency, alongside increased serum 25(OH)D.
Conclusions
Vitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.
Limitations
Short 4-week follow-up, subjective single-domain outcome, modest sample (n=120), and results apply only to people who are already vitamin D deficient.
Supplements Studied
Vitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.