Effects of nutritional interventions on the severity of depressive and anxiety symptoms of women in the menopausal transition and menopause: a systematic review, meta-analysis, and meta-regression
Grigolon RB, Ceolin G, Deng Y, Bambokian A
Published in Menopause
Methodology
Systematic review, meta-analysis and meta-regression of 32 randomized placebo-controlled trials of diet, supplements and nutraceuticals on depressive and anxiety symptoms in the menopausal transition.
Key Findings
Nutritional interventions modestly reduced depressive symptoms (SMD -0.35, 95% CI -0.68 to -0.03) versus placebo, with anxiety data much sparser.
Conclusions
Supplements and dietary interventions offer small benefits for mood in the menopausal transition.
Limitations
Heterogeneous interventions pooled together; few anxiety trials; small effect size.
Supplements Studied
The pooled effect size favored the intervention group over placebo for both DS and AS (DS: standardized mean difference, -0.35 [95% confidence interval, -0.68 to -0.03; P = 0.0351])
The pooled effect size favored the intervention group over placebo for both DS and AS (DS: standardized mean difference, -0.35 [95% confidence interval, -0.68 to -0.03; P = 0.0351])
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.