Folic acid and zinc supplementation and live birth among couples seeking infertility treatment: the FAZST randomized clinical trial
Schisterman EF, Sjaarda LA, Clemons T, Carrell DT, Perkins NJ, Johnstone E, Lamb D, Chaney K, Van Voorhis BJ, Ryan G, Mumford SL
Published in JAMA
Methodology
Large multicentre randomized double-blind placebo-controlled trial of folic acid 5 mg plus zinc 30 mg daily in men from couples seeking infertility treatment.
Key Findings
Folic acid and zinc supplementation did not improve live birth rates or semen quality and increased gastrointestinal side effects.
Conclusions
Well-powered null trial contradicts routine folate-zinc use for sperm quality.
Limitations
Fertility-clinic population; specific dose combination only.
Supplements Studied
Folic acid and zinc supplementation did not improve live birth rates or semen quality
Outcomes Measured
Folic acid and zinc supplementation did not improve live birth rates or semen quality and increased gastrointestinal side effects
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.