Emodin: a metabolite that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
Tuli HS, Aggarwal V, Tuorkey M, Aggarwal D, Parashar NC
Published in Toxicology in Vitro
Methodology
Evidence synthesis of in vitro and animal studies of emodin effects on apoptosis, cell cycle arrest, angiogenesis, metastasis and chemoresistance
Key Findings
Anticancer activity is documented only in cell and animal models, with no clinical efficacy data.
Conclusions
Emodin remains a preclinical anticancer candidate, not a validated therapy.
Limitations
No human trials; publication bias in preclinical literature.
Supplements Studied
One of these natural product metabolites, emodin has present with significant potential to target tumor oncogenic processes: induction of apoptosis and cell cycle arrest, tumor angiogenesis, and metastasis to chemoresistance in malignant cells.
Study Details
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Disclosures
Funding
Not reported
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