Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease (CARET)
Omenn GS, Goodman GE, Thornquist MD, et al.
Published in New England Journal of Medicine
Abstract
Multicenter randomized double-blind placebo-controlled primary prevention trial of beta carotene and retinyl palmitate.
Key Findings
The trial was stopped early: participants receiving beta carotene plus retinyl palmitate had a 28% higher incidence of lung cancer and 17% higher death rate than placebo.
Conclusions
High-dose beta carotene with vitamin A increases lung cancer risk in smokers and asbestos-exposed workers.
Limitations
High-risk exposed population; combination intervention limits attribution to beta carotene alone.
Supplements Studied
The trial was stopped early: participants receiving beta carotene plus retinyl palmitate had a 28% higher incidence of lung cancer and 17% higher death rate than placebo.
The combination of beta carotene and vitamin A increased lung cancer incidence and mortality in smokers and asbestos-exposed workers.
Related Health Concerns
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.