The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Andreux PA, Blanco-Bose W, Ryu D
Published in Nature Metabolism
Methodology
First-in-human randomized placebo-controlled trial of single and multiple ascending doses of Urolithin A in elderly adults
Key Findings
Urolithin A was bioavailable and safe up to 1000 mg and modulated plasma acylcarnitines and skeletal muscle mitochondrial gene expression
Conclusions
Urolithin A is safe in humans and induces a mitochondrial biomarker signature
Limitations
Phase I design; biomarker rather than clinical endpoints
Supplements Studied
Urolithin A was bioavailable and safe up to 1000 mg and modulated mitochondrial gene expression in skeletal muscle
Outcomes Measured
Urolithin A modulated plasma acylcarnitines and skeletal muscle mitochondrial gene expression
Urolithin A was bioavailable and safe up to 1000 mg and modulated plasma acylcarnitines and skeletal muscle mitochondrial gene expression
Study Details
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