Effect of polyphenol compounds on Helicobacter pylori eradication: a systematic review with meta-analysis
Wang Q, Yao C, Li Y, Luo L, Xie F
Published in BMJ Open
Methodology
Systematic review and meta-analysis of randomised controlled trials of polyphenol compounds including liquorice, curcumin, cranberry, garlic and broccoli as adjunct or stand-alone H. pylori treatment, searched to January 2022
Key Findings
Polyphenol compounds including liquorice modestly improved eradication rates as adjuncts, but effects varied by compound and trial quality was uneven.
Conclusions
Adjunct benefit is plausible but the pooled evidence remains moderate at best.
Limitations
Heterogeneous compounds and regimens; several small or poorly reported trials; possible publication bias.
Supplements Studied
This meta-analysis aims to assess the efficacy and safety of polyphenol compounds (curcumin, cranberry, garlic, liquorice and broccoli) in eradicating Helicobacter pylori.
Outcomes Measured
All randomised controlled trials comparing polyphenol compounds with the placebo or used as an adjunct treatment are included in this meta-analysis.
Study Details
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Disclosures
Funding
Not reported
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