N-acetylcysteine, oxidative stress and protein misfolding: a systematic review of clinical evidence
Tenorio MCDS, Graciliano NG, Moura FA, Oliveira ACM, Goulart MOF
Published in Antioxidants
Methodology
Systematic review of clinical studies of N-acetylcysteine on glutathione status, protein oxidation and redox-dependent cellular stress markers.
Key Findings
NAC reliably raised glutathione and reduced markers of protein oxidation and carbonylation across clinical populations.
Conclusions
NAC supports redox conditions required for correct protein folding.
Limitations
Surrogate markers; clinical folding outcomes not measured.
Supplements Studied
NAC reliably raised glutathione and reduced markers of protein oxidation and carbonylation
NAC reliably raised glutathione and reduced markers of protein oxidation and carbonylation across clinical populations.
Outcomes Measured
NAC reliably raised glutathione and reduced markers of protein oxidation and carbonylation across clinical populations
Study Details
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