Effect of lactase supplementation on infant colic: Systematic review of randomized controlled trials
Kozlowska-Jalowska A, Strozyk A, Horvath A
Published in Journal of Pediatric Gastroenterology and Nutrition
Methodology
Systematic review of 5 randomised controlled trials (391 infants) comparing oral lactase with placebo or no intervention in infant colic
Key Findings
Meta-analysis of two RCTs found no difference in crying and fussing duration versus placebo
Conclusions
Enzyme supplementation only helps when the specific enzyme deficiency is the cause of symptoms
Limitations
Few small trials, variable compliance and dosing
Supplements Studied
A meta-analysis of two RCTs found no difference in crying duration and fussing time during 1 week of lactase treatment compared with placebo
Outcomes Measured
A meta-analysis of two RCTs found no difference in crying duration and fussing time during 1 week of lactase treatment compared with placebo
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.