The effect of grape seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: a systematic review and meta-analysis with dose-response analysis
Foshati S, Nouripour F, Sadeghi E, Amani R
Published in Pharmacological Research
Methodology
Systematic review and dose-response meta-analysis of controlled trials of grape seed extract on vascular function measures
Key Findings
Grape seed extract improved flow-mediated dilation and modestly lowered systolic blood pressure, with effects most apparent at shorter durations and moderate doses.
Conclusions
Grape seed extract improves endothelial function and slightly lowers blood pressure.
Limitations
Heterogeneity in extract standardisation and FMD methodology.
Supplements Studied
Grape seed extract supplementation significantly improved flow-mediated dilation and modestly reduced systolic blood pressure.
Outcomes Measured
Grape seed extract supplementation significantly improved flow-mediated dilation.
Study Details
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