Blood Testing for Sensitivity, Allergy or Intolerance to Food
Isabel J. Skypala, et al.
Published in Postgraduate Medical Journal
Abstract
This review discusses the scientific basis and clinical validity of blood-based tests, including food-specific IgG testing, marketed for diagnosing food sensitivity or intolerance.
Methodology
Critical appraisal of the immunological rationale and available evidence for commercial IgG and other blood-based food sensitivity tests.
Key Findings
Food-specific IgG antibodies are commonly detected in healthy, asymptomatic individuals and reflect exposure rather than pathological sensitivity; no validated evidence supports their use for diagnosing food intolerance.
Conclusions
IgG-based food panel testing lacks scientific validity for diagnosing food intolerance or guiding elimination diets and is not recommended by allergy professional bodies.
Limitations
As a narrative review, it does not include a formal quantitative meta-analysis; reliant on interpretation of underlying immunology literature.
Related Health Concerns
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