Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ
Published in Archives of Internal Medicine
Methodology
Meta-analysis of 13 randomised trials of phytonadione and menaquinone-4 on bone loss and fractures.
Key Findings
All but one trial showed improved bone density, and menaquinone-4 was associated with reduced vertebral, hip and non-vertebral fractures, mostly in Japanese cohorts.
Conclusions
Vitamin K, particularly menaquinone-4, may reduce fracture risk, but the evidence base is dominated by small Japanese trials.
Limitations
Geographic and methodological homogeneity limits generalisability; later higher-quality trials did not confirm the effect.
Supplements Studied
Vitamin K supplementation was associated with improved bone density in all but one trial.
Related Health Concerns
Study Details
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