Molecular chaperones and the proteostasis network: therapeutic modulation by small molecules
Hipp MS, Kasturi P, Hartl FU
Published in Nature Reviews Molecular Cell Biology
Methodology
Comprehensive mechanistic review of the cellular proteostasis network, chaperone function and pharmacological chaperone-inducing strategies.
Key Findings
Heat shock protein induction and chemical chaperones such as trehalose and 4-phenylbutyrate improve protein folding capacity in preclinical models.
Conclusions
Protein folding support is well established mechanistically but largely preclinical.
Limitations
No human supplement trials; mechanistic evidence only.
Outcomes Measured
Heat shock protein induction and chemical chaperones such as trehalose and 4-phenylbutyrate improve protein folding capacity in preclinical models
Study Details
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