Citicoline for Acute Ischemic Stroke: A Systematic Review and Formal Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Trials
Secades JJ, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Martínez-Vila E, Ríos J, Oudovenko N
Published in Journal of Stroke and Cerebrovascular Diseases
Methodology
Formal meta-analysis of randomized, double-blind, placebo-controlled trials of citicoline in acute ischemic stroke.
Key Findings
Pooled analysis suggested a small increase in the odds of global recovery with citicoline, but the effect disappeared in the largest, most recent trials.
Conclusions
Any benefit of citicoline in acute ischemic stroke is small and not confirmed by the largest modern trial.
Limitations
Authors include manufacturer employees; effect estimates dominated by older, smaller trials with weaker methodology.
Supplements Studied
Pooled analysis suggested a small increase in the odds of global recovery with citicoline.
Related Health Concerns
Study Details
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Disclosures
Funding
Ferrer Grupo (manufacturer)
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