Vitamin B12 and Neurological Function
Reynolds E
Published in Lancet Neurology
Abstract
Comprehensive review of vitamin B12's role in neurological function and the neurological consequences of deficiency.
Methodology
Review in Lancet Neurology of vitamin B12 metabolism, the neurological and psychiatric consequences of deficiency, and diagnostic and treatment considerations.
Key Findings
B12 deficiency can cause subacute combined degeneration, peripheral neuropathy, cognitive impairment and mood disturbance, sometimes without anaemia or macrocytosis. Serum B12 alone is an insensitive test; methylmalonic acid and homocysteine improve detection. Neurological recovery depends heavily on how early treatment begins, and folate supplementation can mask haematological signs while neurological damage progresses.
Conclusions
Early recognition and prompt repletion of B12 deficiency are essential because delayed treatment risks irreversible neurological injury; clinicians should not rely on serum B12 or blood counts alone.
Limitations
Narrative review without systematic search or pooled estimates; much supporting evidence is observational or from case series rather than controlled trials.
Supplements Studied
Vitamin B12 deficiency causes a spectrum of neurological disturbances, and early recognition and repletion are essential to prevent irreversible damage.
Outcomes Measured
Vitamin B12 deficiency causes a spectrum of neurological disturbances, and early recognition and repletion are essential to prevent irreversible damage.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.