Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects
Kikuchi M, Ushida Y, Shiozawa H, Umeda R
Published in World Journal of Gastroenterology
Methodology
Randomized, placebo-controlled, double-blind trial in Japanese men with fatty liver; broccoli sprout capsules containing glucoraphanin (n=24) or placebo (n=28) for 2 months; liver enzymes and urinary 8-OHdG measured, with a parallel rat model assessing hepatic glutathione S-transferase activity
Key Findings
Two months of glucoraphanin supplementation significantly reduced liver function markers and the oxidative stress marker 8-OHdG versus placebo; the animal arm showed increased hepatic glutathione S-transferase activity.
Conclusions
Sulforaphane precursors improve hepatic markers in men with fatty liver, consistent with induction of phase II antioxidant enzymes.
Limitations
Small single-sex sample, surrogate markers, phase II enzyme activity measured in rats rather than humans, industry-linked authorship.
Supplements Studied
Dietary supplementation with BS extract containing SF precursor GR for 2 mo significantly decreased liver function markers
Outcomes Measured
Dietary supplementation with BS extract containing SF precursor GR for 2 mo significantly decreased liver function markers
Study Details
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Disclosures
Funding
Non-commercial and industry support
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