Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis
Veronese N, Sergi G, Stubbs B, Bourdel-Marchasson I, Tessier D, Maggi S, Manzato E, Vandenput L
Published in European Geriatric Medicine
Methodology
Systematic review and meta-analysis of randomized placebo-controlled trials of acetyl-L-carnitine in diabetic peripheral neuropathy.
Key Findings
Acetyl-L-carnitine significantly improved pain scores and nerve conduction velocity compared with placebo in people with diabetic peripheral neuropathy, with a good tolerability profile.
Conclusions
Acetyl-L-carnitine is a reasonable adjunct for diabetic peripheral neuropathy symptoms, though it does not replace glycaemic control.
Limitations
Few trials, moderate sample sizes, industry involvement in the largest studies, and limited long-term follow-up.
Supplements Studied
Meta-analysis in diabetic peripheral neuropathy found significant improvement in pain scores and nerve conduction velocity versus placebo.
Acetyl-L-carnitine significantly improved pain scores and nerve conduction velocity compared with placebo in people with diabetic peripheral neuropathy, with a good tolerability profile.
Related Health Concerns
Study Details
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Disclosures
Funding
No commercial funding reported; academic authors.
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