Effectiveness of oral vitamin D supplementation in lessening disease severity among patients with psoriasis: A systematic review and meta-analysis of randomized controlled trials
Theodoridis X, Grammatikopoulou MG, Stamouli EM, Talimtzi P, Pagkalidou E, Zafiriou E, Haidich AB, Bogdanos DP
Published in Nutrition
Methodology
Systematic review of PubMed, Embase, Cochrane Central and grey literature for RCTs of oral vitamin D versus placebo in psoriasis; 4 studies qualitative, 3 pooled with random-effects modelling and Hartung-Knapp adjustment.
Key Findings
Vitamin D improved PASI at 6 months (MD -0.92; 95% CI -1.72 to -0.11), but after the Hartung-Knapp adjustment the effect became non-significant (MD -0.92; 95% CI -2.21 to 0.38).
Conclusions
A favorable effect of oral vitamin D supplementation in patients with psoriasis could not be verified.
Limitations
Only three trials poolable; small samples; heterogeneous dosing regimens; imprecise pooled estimate.
Supplements Studied
Vitamin D supplementation was effective in ameliorating the PASI score after 6 mo of intervention (mean difference [MD] = -0.92, 95% CI = -1.72 to -0.11). However, after the Hartung-Knapp adjustment, the results became non-significant.
Related Health Concerns
Study Details
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Disclosures
Funding
Academic/institutional
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.