Oral L-arginine supplementation and endothelial function: a meta-analysis of randomized controlled trials
Bai Y, Sun L, Yang T, Sun K, Chen J, Hui R
Published in American Journal of Clinical Nutrition
Methodology
Meta-analysis of randomized trials of oral L-arginine measuring flow-mediated dilation as an index of nitric oxide-dependent endothelial function.
Key Findings
L-arginine improved flow-mediated dilation overall, but benefit was confined to participants with impaired baseline endothelial function.
Conclusions
Arginine raises nitric oxide-mediated vasodilation only where endothelial function is already impaired.
Limitations
Heterogeneity across trials; publication bias not excluded.
Supplements Studied
L-arginine improved flow-mediated dilation, but benefit was confined to impaired baseline endothelial function
Outcomes Measured
L-arginine improved flow-mediated dilation overall, but benefit was confined to participants with impaired baseline endothelial function
L-arginine improved flow-mediated dilation overall, but benefit was confined to participants with impaired baseline endothelial function.
Study Details
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