Potentiation of warfarin by dong quai
Page RL, Lawrence JD
Published in Pharmacotherapy
Methodology
Case report of a 46-year-old woman with atrial fibrillation stabilised on warfarin who took dong quai concurrently for four weeks, with prothrombin time and INR monitoring before and after withdrawal
Key Findings
INR and prothrombin time more than doubled during concurrent dong quai use and normalised a month after stopping the herb.
Conclusions
Dong Quai contains coumarin derivatives and can dangerously potentiate anticoagulation.
Limitations
Single case; mechanism unconfirmed; no rechallenge.
Supplements Studied
A 46-year-old African-American woman with atrial fibrillation stabilized on warfarin experienced a greater than 2-fold elevation in prothrombin time and international normalized ratio after taking dong quai concurrently for 4 weeks.
Study Details
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Disclosures
Funding
Not reported
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.