Coenzyme Q10 Supplementation in Statin-Associated Muscle Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Qu H, Guo M, Chai H, Wang WT, Ga ZY, Shi DZ
Published in Journal of the American Heart Association
Methodology
Systematic review and meta-analysis of 12 randomized controlled trials assessing CoQ10 for statin-associated muscle symptoms.
Key Findings
CoQ10 supplementation was associated with modest reductions in statin-related muscle pain, weakness, cramp and tiredness scores, but not in creatine kinase levels.
Conclusions
CoQ10 may modestly improve subjective statin-associated muscle symptoms, though the largest rigorous crossover trials show no benefit.
Limitations
Included trials were small and heterogeneous with subjective endpoints; results conflict with the best-designed individual trials.
Supplements Studied
CoQ10 was associated with modest reductions in statin-related muscle pain, weakness, cramp and tiredness scores, but not creatine kinase.
Outcomes Measured
CoQ10 supplementation ameliorated statin-associated muscle symptoms, implying that CoQ10 supplementation may be a complementary approach to manage statin-induced myopathy.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Chinese national and academic research grants
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.