Infantile flexural seborrhoeic dermatitis. Neither biotin nor essential fatty acid deficiency
Erlichman M
Published in Archives of Disease in Childhood
Methodology
Controlled clinical trial in infants with flexural seborrhoeic dermatitis given biotin versus control, with clinical rash assessment alongside biochemical testing of biotin and essential fatty acid status.
Key Findings
Biotin supplementation produced no measurable improvement in infantile flexural seborrhoeic dermatitis compared with control, and affected infants showed no evidence of biotin or essential fatty acid deficiency.
Conclusions
No beneficial effect could be confirmed, and it is therefore unlikely that this disease is caused by biotin deficiency.
Limitations
Very old study with limited reporting by modern standards, small numbers, and no standardised severity scoring or blinding details.
Supplements Studied
No beneficial effect could be confirmed, and it is therefore unlikely that this disease is caused by biotin deficiency.
Related Health Concerns
Study Details
Access Study
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