The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: a preliminary randomized, double-blind, placebo-controlled cross-over design study
Jetly R, et al.
Published in Psychoneuroendocrinology
Methodology
Preliminary randomized, double-blind, placebo-controlled crossover trial of the synthetic cannabinoid nabilone in military personnel with PTSD-associated nightmares, with a washout between periods.
Key Findings
In a crossover trial in military personnel with treatment-refractory PTSD, nabilone reduced nightmare severity on the CAPS recurring-dream item compared with placebo, with improvements also reported in global clinical impression and general wellbeing.
Conclusions
In this small sample NAB provided significant relief for military personnel with PTSD, indicating that it shows promise as a clinically-relevant treatment for patients with nightmares and a history of non-response to traditional therapies.
Limitations
Very small sample (n=10), short treatment periods, potential unblinding from psychoactive effects, and a highly selected non-responder population limiting generalisability.
Related Health Concerns
Study Details
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