A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine
Porpora MG, Brunelli R, Costa G, Imperiale L, Krasnowska EK, Lundeberg T, Nofroni I, Piccioni MG, Pittaluga E, Ticino A, Parasassi T
Published in Evidence-Based Complementary and Alternative Medicine
Methodology
Observational cohort study of women with ovarian endometriomas awaiting laparoscopy, comparing three months of oral N-acetylcysteine with untreated controls using ultrasound cyst measurement and pain scores.
Key Findings
Endometrioma size decreased in the N-acetylcysteine group while it increased in controls, with reduced pain and a number of participants cancelling scheduled surgery.
Conclusions
N-acetylcysteine may reduce endometrioma size and pain, warranting randomised confirmation.
Limitations
Not randomised or blinded; single centre; small sample; short follow-up.
Supplements Studied
Endometrioma size decreased with N-acetylcysteine while it increased in untreated controls.
Related Health Concerns
Study Details
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Disclosures
Funding
Academic (Sapienza University of Rome)
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