Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
Liu S, DAmico D, Shankland E
Published in JAMA Network Open
Methodology
Randomized double-blind placebo-controlled 4-month trial of Urolithin A 1000 mg daily in adults aged 65-90
Key Findings
The primary endpoints of six-minute walk distance and muscle ATP production did not differ from placebo, though muscle endurance in the hand and leg improved and plasma acylcarnitines and ceramides fell
Conclusions
Urolithin A did not improve the primary functional endpoints but showed secondary signals for muscle endurance and mitochondrial biomarkers
Limitations
Primary endpoints null; modest sample; industry sponsored
Supplements Studied
The primary endpoints of six-minute walk distance and muscle ATP production did not differ from placebo
Outcomes Measured
Muscle endurance in the hand and leg improved despite null primary endpoints
Six-minute walk distance and muscle ATP production did not differ from placebo
Related Health Concerns
Study Details
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