rct
    2002
    High Quality

    Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

    Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM

    Published in New England Journal of Medicine

    Key Findings

    Lifestyle intervention reduced incidence of type 2 diabetes by 58% and metformin by 31% compared with placebo over 2.8 years.

    Conclusions

    Addressing the underlying glycaemic driver is the most effective way to prevent symptoms such as excessive thirst.

    Limitations

    Older trial; symptom endpoints not reported directly.

    Outcomes Measured

    Blood Sugar Balance

    Lifestyle intervention reduced the incidence of type 2 diabetes by 58 percent versus placebo.

    Related Health Concerns

    Excessive Thirst
    Type 2 Diabetes

    Study Details

    Year:2002
    Sample Size:3,234
    Duration:145 weeks
    Quality Score:9/10

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