meta_analysis
    2013
    High Quality

    Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals

    Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E

    Published in The Lancet

    Methodology

    Meta-analysis of individual participant data from 13 folic acid trials involving 49,621 participants.

    Key Findings

    Folic acid supplementation had no significant effect on overall cancer incidence (RR 1.06) or on site-specific cancers during the trial periods.

    Conclusions

    Folic acid supplementation for up to 5 years does not increase or decrease cancer incidence.

    Limitations

    Median treatment duration ~5 years; long-term effects unresolved.

    Supplements Studied

    Folic acid supplementation did not substantially increase or decrease incidence of site-specific or overall cancer.

    Related Health Concerns

    Cancer

    Study Details

    Year:2013
    Sample Size:49,621
    0
    Quality Score:9/10

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