Effects of dietary and supplement interventions on circulating leptin and leptin sensitivity: a systematic review
Yang N, Zhang Q, Yang H
Published in Obesity Reviews
Methodology
Systematic review of randomized trials of nutritional supplements reporting circulating leptin and leptin-to-adiposity ratios in adults with overweight or obesity.
Key Findings
Reductions in circulating leptin largely tracked fat mass loss rather than independent improvements in leptin signalling.
Conclusions
Most supplement-induced leptin changes are secondary to weight loss, not direct leptin sensitisation.
Limitations
Leptin sensitivity rarely measured directly; heterogeneity in interventions.
Outcomes Measured
Reductions in circulating leptin largely tracked fat mass loss rather than independent improvements in leptin signalling
Study Details
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