Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials
Mott A, Bradley T, Wright K, Cockayne ES, Shearer MJ, Adamson J, Lanham-New SA, Torgerson DJ
Published in Osteoporosis International
Methodology
Systematic review and meta-analysis of 36 randomised trials of vitamin K1 or K2 on bone mineral density and fracture outcomes.
Key Findings
No consistent effect on bone mineral density; apparent fracture reductions were driven by lower-quality Japanese trials and disappeared in higher-quality studies.
Conclusions
Current evidence does not support vitamin K supplementation for fracture prevention in the general population.
Limitations
Substantial heterogeneity in dose, form and population; publication bias detected.
Supplements Studied
Apparent fracture benefits of vitamin K disappeared when analysis was restricted to higher-quality trials.
No consistent effect of vitamin K on bone mineral density; fracture reductions were confined to lower-quality trials.
Outcomes Measured
Vitamin K showed no consistent effect on bone mineral density or fractures in higher-quality trials.
No consistent effect on bone mineral density; apparent fracture reductions were driven by lower-quality Japanese trials and disappeared in higher-quality studies.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.