Omega-3 fatty acids, BDNF and synaptic plasticity: a systematic review of human and animal evidence
Bhatia HS, Agrawal R, Sharma S, Huo YX, Ying Z, Gomez-Pinilla F
Published in PLOS ONE
Methodology
Experimental and translational studies of omega-3 deficiency and repletion on hippocampal BDNF signalling, synapsin and learning performance.
Key Findings
Omega-3 deficiency reduced BDNF and synapsin levels and impaired spatial learning, while repletion restored synaptic plasticity markers.
Conclusions
Omega-3 status directly modulates molecular substrates of synaptic plasticity.
Limitations
Predominantly animal data.
Supplements Studied
Omega-3 deficiency reduced BDNF and synapsin levels and impaired spatial learning, while repletion restored synaptic plasticity markers
Outcomes Measured
Omega-3 deficiency reduced BDNF and synapsin levels and impaired spatial learning, while repletion restored synaptic plasticity markers
Study Details
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