Leucine and mTORC1 signalling in human skeletal muscle: a systematic review of intervention trials
Wilkinson DJ, Hossain T, Limb MC, Phillips BE, Lund J, Williams JP
Published in Journal of Physiology
Methodology
Review of human muscle-biopsy trials measuring mTORC1 pathway phosphorylation and muscle protein synthesis after leucine or leucine metabolite ingestion.
Key Findings
Leucine and its metabolite HMB acutely activated mTORC1 signalling and raised muscle protein synthesis, with leucine the more potent stimulus.
Conclusions
Leucine availability is the primary nutritional activator of mTORC1 in human muscle.
Limitations
Acute biopsy endpoints; limited long-term hypertrophy data.
Supplements Studied
Leucine and its metabolite HMB acutely activated mTORC1 signalling and raised muscle protein synthesis
Outcomes Measured
Leucine and its metabolite HMB acutely activated mTORC1 signalling and raised muscle protein synthesis
Leucine and its metabolite HMB acutely activated mTORC1 signalling and raised muscle protein synthesis, with leucine the more potent stimulus.
Study Details
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