Antiepileptic drugs and bone health: vitamin D and fracture risk
Lee RH, Lyles KW, Colon-Emeric C
Published in Annals of Pharmacotherapy
Key Findings
Enzyme-inducing antiepileptic drugs accelerate vitamin D catabolism and are associated with reduced bone mineral density and increased fracture risk.
Conclusions
Vitamin D status should be monitored and supplemented in people on long-term antiepileptic therapy.
Limitations
Mostly observational data, variable drug regimens.
Supplements Studied
Enzyme-inducing antiepileptic drugs increase vitamin D catabolism and are associated with reduced bone mineral density.
Outcomes Measured
Enzyme-inducing antiepileptic drugs accelerate vitamin D catabolism and are associated with reduced bone mineral density and increased fracture risk.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.