The impact of baseline potassium intake on the dose-response relation between sodium reduction and blood pressure change: systematic review and meta-analysis of randomized trials
Huang L, Neal B, Wu JHY, Marklund M, He FJ, Chalmers J, Trieu K
Published in Journal of Human Hypertension
Methodology
Systematic review and meta-regression of 68 randomized trials with sodium and potassium intake measured by 24-hour urine collection
Key Findings
Baseline potassium intake was not significantly associated with the blood pressure reduction achieved by a 50 mmol lowering of sodium intake; higher baseline blood pressure predicted greater response.
Conclusions
Sodium-potassium interaction on blood pressure could not be confirmed; sodium reduction benefits appear largely independent of baseline potassium.
Limitations
Limited variation in potassium intake across trials, meta-regression is observational across studies, heterogeneous populations
Supplements Studied
Sodium and potassium appear to interact with each other in their effects on blood pressure with potassium supplementation having a greater blood pressure lowering-effect when sodium intake is high.
Outcomes Measured
Multivariable meta-regression... did not identify a significant association of baseline potassium intake levels with the blood pressure reduction achieved with a 50 mmol lowering of sodium intake.
Study Details
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Disclosures
Funding
Academic (The George Institute for Global Health)
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.