A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements
Powers CN, Setzer WN
Published in In Silico Pharmacology
Methodology
In-silico molecular docking screen of phytochemicals from herbal supplements, including Dioscorea villosa constituents, against oestrogen receptors.
Key Findings
Several supplement phytochemicals docked at oestrogen receptor sites, but diosgenin showed limited receptor affinity relative to known phytoestrogens.
Conclusions
Computational data do not support a strong direct oestrogenic action for wild yam constituents.
Limitations
Purely computational; no cellular, animal or human confirmation.
Supplements Studied
Diosgenin showed limited oestrogen receptor affinity relative to known phytoestrogens in molecular docking.
Outcomes Measured
Diosgenin showed limited oestrogen receptor affinity relative to known phytoestrogens.
Study Details
Access Study
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.