The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis
Nozari E, et al
Published in Clinical Nutrition Research
Methodology
Randomized controlled trial in patients with multiple sclerosis; serum homocysteine, anemia markers and a quality-of-life questionnaire were assessed before and after supplementation.
Key Findings
Supplementation with vitamin B12 plus folic acid significantly reduced serum homocysteine and improved haematological anemia indices and quality-of-life scores compared with the control condition in patients with multiple sclerosis.
Conclusions
Vitamin B12 and folic acid supplementation lowered homocysteine and improved anemia status and quality of life.
Limitations
Small sample (n=50), single-centre, short follow-up, and surrogate biochemical endpoints rather than disability or relapse outcomes.
Supplements Studied
Serum homocysteine level decrease and anemia status improvement with vitamin B12 and folic acid supplementation reveal the potential role of these two vitamins in improving the life quality of MS patients.
Serum homocysteine level decrease and anemia status improvement with vitamin B12 and folic acid supplementation reveal the potential role of these two vitamins in improving the life quality of MS patients.
Related Health Concerns
Study Details
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.