Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y
Published in Proceedings of the National Academy of Sciences
Methodology
Randomized, double-blind, placebo-controlled chemoprevention trial; 100 mg chlorophyllin three times daily for 4 months in Qidong, China
Key Findings
Chlorophyllin produced a 55% reduction in median urinary aflatoxin-N7-guanine adduct levels versus placebo.
Conclusions
Prophylactic chlorophyllin can reduce the biologically effective dose of aflatoxin in a high-exposure population.
Limitations
Biomarker endpoint rather than cancer incidence; single high-exposure population; short duration relative to carcinogenesis.
Supplements Studied
One hundred and eighty healthy adults from Qidong were randomly assigned to ingest 100 mg of chlorophyllin or a placebo three times a day for 4 months.
Study Details
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Disclosures
Funding
Public research funding (NIH/NCI)
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